Arsenal will host Manchester United in the pick of the FA Cup fourth round ties after both clubs recorded comfortable third round victories.
Manchester City, Chelsea and Tottenham are other members of the 'big six' to make the fourth round but Premier League leaders Liverpool made an early exit after a much-changed starting XI went down 2-1 at Wolves.
Top flight sides pay the price for rotation
Jurgen Klopp made nine changes to the side that lost to Man City in the Premier League on Thursday night including giving full debuts to 17-year-old midfielder Curtis Jones and 18-year-old Rafael Camacho. Dutch defender Ki-Jana Hoever, just 16-years-old, also made his debut after just five minutes when he came on to replace the injured Dejan Lovren.
Wolves - practically at full strength - deservedly took the lead towards the end of the first half through Raul Jimenez, and shortly after Divock Origi had equalised early in the second half Ruben Neves smashed home the winner with a superb long-range strike.
Wolves' reward for their deserved victory is a fourth round tie away to the winners of the Shrewsbury v Stoke replay. Nuno Santo's men are available to back at 17.00 in the FA Cup winner market.
Newport County and non-league outfit Barnet produced big shocks during round three, getting the better of Leicester and Sheffield United respectively. The League Two Welsh outfit will travel to Middlesbrough in round four, while Barnet will host Championship side Brentford.
Bournemouth, Cardiff, Fulham and Huddersfield are the other Premier League clubs to make an early exit from this season's competition.
City remain favourites but all eyes drawn to Arsenal v United
Manchester City - who beat Rotherham 7-0 in the previous round - head the FA Cup winner market, and Pep Guardiola's men shortened to 3.60 on Monday night after they were drawn at home to Premier League strugglers Burnley in round four.
Tottenham - available to back at 9.20 - were another side to win 7-0 in the previous round and they will face Crystal Palace at Selhurst Park next, while FA Cup holders Chelsea were drawn at home to Sheffield Wednesday or Luton in round four after beating Nottingham Forest on Saturday. The Blues can be backed at 6.20 to defend their crown.
But undoubtedly the tie of the round will be a first ever FA Cup encounter at the Emirates Stadium between Arsenal and Manchester United. The famous clubs have met 15 times previously in the same competition with United holding the advantage with seven victories to Arsenal's six (two draws).
The Red Devils can be backed at 9.60 to lift the trophy in May, while the Gunners are currently trading at 14.00.
FA Cup Fourth Round Draw in Full: (*PL teams in bold)
- Swansea v Gillingham - AFC Wimbledon v West Ham - Shrewsbury or Stoke v Wolves - Millwall v Everton - Brighton v West Brom - Bristol City v Bolton - Accrington Stanley v Derby or Southampton - Doncaster v Oldham - Chelsea v Sheff Wed or Luton - Newcastle or Blackburn v Watford - Middlesbrough v Newport County - Man City v Burnley - Barnet v Brentford - Portsmouth v QPR - Arsenal v Man Utd - Crystal Palace v Tottenham