Just seven Premier League clubs entered the draw for the fifth round of the FA Cup after weekend defeats for north London rivals Arsenal and Tottenham in addition to the shock exits of Everton and West Ham.
Only five of those seven remaining are guaranteed to be playing in the next round with Wolves - available to back at 12.50 in the FA Cup Winner market - and Brighton, 30.00, facing replays against Shrewsbury and West Brom respectively.
City shorten as Chelsea get United
Another side facing a replay is League Two outfit Newport County after a 93rd minute equaliser away to Middlesbrough - scored by former Boro youth player Matthew Dolan - continued their excellent cup run, and both sides will be licking their lips at the prospect of facing Premier League champions Manchester City in round five.
City shortened to 2.42 to win the FA Cup following this seemingly kind draw but it was Chelsea being draw at home to Manchester United that really strengthened City's grip at the head of the market.
The Blues last faced United in the FA Cup as recently as last May when Antonio Conte's men got the better of Jose Mourinho's side 1-0 in the final at Wembley. Much has changed since that day, including the two managers, and whoever comes out of this tie successful will become the main challenger to City winning the competition.
Chelsea and United both trade at around the 6.60 mark in the Winner market.
Draw opens up for London sides
Premier League sides Crystal Palace, 12.50, and Watford, 16.00, will now fancy a decent cup run after seeing the draw open up. The Eagles will travel to League One outfit Doncaster in round five while the Hornets will face the winners of the QPR v Portsmouth replay.
There will be at least two non-Premier League sides in the quarter final after AFC Wimbledon were drawn at home to Millall, while Swansea will host the winners of the Barnet v Brentford tie.
FA Cup Fifth Round Draw in Full: (*PL teams in bold)
- Bristol City v Shrewsbury/Wolves - AFC Wimbledon v Millwall - Doncaster v Crystal Palace - Middlesbrough/Newport v Man City - Chelsea v Man United - Swansea v Barnet/Brentford - Portsmouth/QPR v Watford - Brighton/West Brom v Derby