Ole Gunnar Solskjær made it eight wins from eight at Arsenal in the FA Cup on Friday and now only Burnley and Leicester stand in the way of making it the perfect 10.
The Norwegian even had the luxury of giving Marcus Rashford a rest at the Emirates, and he will surely return to the side here, despite Romelu Lukaku impressing with a pair of assists.
Paul Pogba remains in top form in his new more advanced position, and with United now just three points off the top four, you would have to consider them as favourites to finish above both Chelsea and Arsenal.
Anthony Martial was also on the bench at Arsenal, but he still came on and scored, and given Alexis Sanchez's lack of minutes, I would expect the Frenchman to be back in the XI ahead of the Chilean.
Clarets hoping for a better visit to Manchester
Burnley make their second trip to Manchester in the space of three days as they were at the Etihad on Saturday in the FA Cup fourth round. A 5-0 loss was probably roughly what was expected given City's squad size and form, and Sean Dyche picked a team with an eye on this fixture.
Prior to that cup defeat, the Clarets had been unbeaten in five - four wins and a draw - and after things had been looking a little shaky, they come into the match three points clear of the relegation zone.
Obviously the brief from the manager will be to get plenty of men behind the ball and try and frustrate the hosts - a tactic that almost paid off at Spurs in December - and they will take heart from the fact that their last two away games in the league saw them win 2-1 at Huddersfield and draw 0-0 at Watford.
A United clean sheet is not a given
United backers won't get much better than £0.25 in the £1 for this one as they are trading at around the 1.27 mark. It's hard to argue with that given their improvement under Solskjær, but they did only narrowly beat Brighton last time out at Old Trafford, and they appear to be a team who are more suited to playing on the counter.
The draw is 6.80, which is a result that Arsenal, Crystal Palace and Wolves have got at Manchester United this season. They were all during Jose Mourinho's tenure though, obviously, and it would take either a sub-par United or an excellent Burnley performance for the spoils to be shared.
An even more unlikely away win is priced up at 14.00, which seems short to me given that the visitors were above 30/1 to win at City on Saturday.
A bet I do quite like though is Man United to win and both teams to score. It's an outcome that has happened in United's last four home league games - three of which were under Solskjær.
It can be backed at around the 2.80 mark, and that feels like a bit of value.
Plenty of goals for in-form attackers
The Betfair layers are predicting goals and I wouldn't disagree with them. Over 2.5 has landed in United's last five at home, and five of the eight post Mourinho.
Marcus Rashford, Anthony Martial, Paul Pogba, Romelu Lukaku and even Alexis Sanchezhave all scored goals in recent games, and they have other players who chip in too.
Odds of 1.54 doesn't overly entice me however, so I'd much rather back Over 3.5 Goals at 2.42. The visitors have conceded 22 times on their travels this term, and if they go behind early, Dyche will be forced to adopt a more attacking approach.
For those of you who don't think that there will be many goals, Under 2.5 is around the 2.68mark.
Same Game Multi
Marcus Rashford has to feature in my same game multi as he's been on fire since Solskjær arrived at the club. He has found the net in each of his last four starts and he's scored five in his last six Premier League matches.
I have already outlined why I believe United aren't a certainty for a clean sheet in this one, which is why I like Rashford to score, United to win and BTTS. That little combination pays just shy of 4/1 on the Betfair Sportsbook.