Southampton v Man Utd Saturday, 17:30 Live on BT Sport
Along with Crystal Palace, Southampton are the only side without a home win in the Premier League this season.
They've also managed just four goals in six games in front of their own fans and suffered five defeats out of seven away from St Mary's.
The meagre haul of eight points from 13 games leaves Mark Hughes' men in the bottom three and only goal difference keeps them above Cardiff and Fulham.
Starting with this one, from now until January 2nd, five of their next eight games are against Man Utd, Spurs, Arsenal, Man City and Chelsea so no wonder Hughes is considered the red-hot favourite in the Next Manager to Leave market.
Away days suiting United
It's a tough watch for the United faithful at Old Trafford and there are no signs of a corner being turned there after a 0-0 against Crystal Palace and a last-gasp 1-0 victory over Young Boys of Switzerland in the last week.
But away from home it's been a different story. True, they lost the derby at Man City but, in their three previous road trips, Jose Mourinho had guided them to an excellent 2-1 win away at Juventus, a 2-1 success at Bournemouth and come within a whisker of winning at then unbeaten Chelsea, only conceding a goal in added time in a 2-2 draw.
Sitting 14 points off the lead with a goal difference of -1 highlights the problems at United so let's not pretend that the light at the end of the tunnel is coming into view quickly.
But back-to-back clean sheets and qualification for the knockout phases of the Champions League give them something to build on and this looks an obvious opportunity to start a climb towards the top four again.
Mourinho's men odds-on
On first glance, many may baulk at backing Man Utd at 1.92 away from home.
Southampton are 4.60 to pick up their first home win while The Draw is 3.70.
But this looks a more palatable price than the 1.3 United would likely be at home and, for now, the Red Devils look more of a threat on the road.
One way to look at this is analysing United's goal tally on the road. They've netted two goals or more in seven of their nine away games in all comps and scoring twice at St. Mary's will likely be enough against their goal-shy opponents.
When taking that angle, getting nearly even money about United suddenly makes much more appeal.
Some other options include Man Utd to win to nil at 3.25 and the 2-1 scoreline at 9.60. The visitors have won by that margin five times this season although I'm reluctant about giving Southampton a goal.
In that case, preference is for Man Utd to win 2-0 at 11.00 and I'll have a small play on that.
David de Gea has just been signed up for another year so how about the Spanish goalkeeper celebrating with a clean sheet.
Martial main man
Four of Man Utd's last five Premier League away goals have been scored by Anthony Martial and only Harry Kane and Pierre-Emerick Aubameyang (5) have netted more away PL goals than the Frenchman this season.
Martial is 2.38 to add another on Saturday although it doesn't leap off the page.
Juan Mata with three goals in 11 games is a possible at 3.95 while Wednesday night's hero Marouane Fellaini is 5.40 to get Jose excited again.
In the Same Game Multi market, Martial to score in a Man Utd win is 13/5.
Southampton are winless in seven home Premier League matches against Manchester United (W0 D2 L5) since a 1-0 win in August 2003.